Chemical element concentrations in cord whole blood and the risk of preterm birth for pregnant women in Guangdong, China: Robustness Under Distribution Shift

Authors

  • Mitchell Sullivan Author
  • Parker Campbell Author
  • Reed Hayes Author

Keywords:

environmental exposure assessment, robustness under distribution shift, evidence synthesis, reproducibility, research evaluation

Abstract

Robustness depends on whether conclusions remain stable when the data distribution, case mix, prevalence, or operating environment differs from the reported setting. This structured evidence review evaluates "Chemical element concentrations in cord whole blood and the risk of preterm birth for pregnant women in Guangdong, China" alongside nine author-disjoint, topically matched publications in environmental exposure assessment. It compares construct definitions, evaluation choices, operating assumptions, and reported limitations instead of treating bibliographic similarity as empirical equivalence. Viewed through robustness under distribution shift, the map separates claims supported by the available record from questions that still require full-text extraction, replication, or new experiments. The synthesis is interpretive rather than meta-analytic and therefore does not present a pooled effect estimate or a new causal result. The resulting agenda uses prespecified shift scenarios, subgroup analysis, calibration checks, and post-deployment monitoring to locate failure boundaries.

References

  1. Wang, Z., Huang, S., Zhang, W., Zeng, X., Chu, C., Li, Q., Cui, X., Wu, Q., Dong, G., Huang, J., Liu, L., Tan, W., Shang, X., Kong, M., & Deng, F. (2022). Chemical element concentrations in cord whole blood and the risk of preterm birth for pregnant women in Guangdong, China. Ecotoxicology and Environmental Safety, 247, 114228. https://doi.org/10.1016/j.ecoenv.2022.114228
  2. Zhou, X., Li, W., Wang, X., & Wang, Y. (2025). Health risk assessment of indoor formaldehyde exposure across Chinese residences: Effects of building material grades. Journal of Hazardous Materials, 490, 137831. https://doi.org/10.1016/j.jhazmat.2025.137831
  3. Ye, W., Little, J.-C., Won, D., & Zhang, X. (2014). Screening-level estimates of indoor exposure to volatile organic compounds emitted from building materials. Building and Environment, 75, 58-66. https://doi.org/10.1016/j.buildenv.2014.01.018
  4. Wyatt, B. (2025). VOC Exposure and Indoor Air Quality: A Practical Framework for Residential Risk Mitigation. SSRN Electronic Journal. https://doi.org/10.2139/ssrn.5348101
  5. Harčárová, K., Vilčeková, S., & Balintova, M. (2020). Building Materials as Potential Emission Sources of VOC in the Indoor Environment of Buildings. Key Engineering Materials, 838, 74-80. https://doi.org/10.4028/www.scientific.net/kem.838.74
  6. Opitz, P., Matysik, S., & Herbarth, O. (2017). Health Risk Assessment of Indoor Volatile Organic Compounds (VOC) considering Long-term trend of VOC. Journal of Environmental and Occupational Science, 1. https://doi.org/10.5455/jeos.20170113084246
  7. “Jensen” Zhang, J., Chen, W., Liu, N., Guo, B.-B., & Zhang, Y. (2022). Testing and Reducing VOC Emissions from Building Materials and Furniture to Improve Indoor Air Quality>. Handbook of Indoor Air Quality, 1-46. https://doi.org/10.1007/978-981-10-5155-5_53-1
  8. Li, X., Zheng, N., Yu, Y., An, Q., & Chen, C. (2025). Comprehensive indoor phthalate risk assessment: A multimedia exposure framework for quantifying population health risk and disease burden. Journal of Hazardous Materials, 499, 140045. https://doi.org/10.1016/j.jhazmat.2025.140045
  9. Jianyin Xiong,, Yinping Zhang,, & Shaodan Huang, (2011). Characterisation of VOC and Formaldehyde Emission from Building Materials in a Static Environmental Chamber: Model Development and Application. Indoor and Built Environment, 20(2), 217-225. https://doi.org/10.1177/1420326x103874801
  10. Brinke, J.-T., Selvin, S., Hodgson, A.-T., Fisk, W.-J., Mendell, M.-J., Koshland, C.-P., & Daisey, J.-M. (1998). Development of New Volatile Organic Compound (VOC) Exposure Metrics and their Relationship to "Sick Building Syndrome" Symptoms. Indoor Air, 8(3), 140-152. https://doi.org/10.1111/j.1600-0668.1998.t01-1-00002.x

Downloads

Published

2026-08-27

Issue

Section

Review Article