Digital Biomarkers for Neurodegenerative Disease Monitoring

This review examines digital biomarkers for neurodegenerative disease monitoring. The organizing question is which sensor-derived measures demonstrate analytical validity, clinical validity, and meaningful longitudinal change. Ten related scholarly sources are synthesized through a decision-centered framework spanning problem definition, mechanism, measurement, evaluation, implementation, and governance. The review does not invent experiments, pooled estimates, or unreported quantitative results. It instead evaluates the strength and transferability of the available evidence, with particular attention to treating device-specific behavioural features as disease-specific biomarkers. The resulting framework links technical or empirical performance to explicit use conditions and identifies tests that should precede wider adoption in remote monitoring and precision neurology.

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8. Song, J., Cho, E., Lee, H., Lee, S., Kim, S., & Kim, J. (2025). Development of Neurodegenerative Disease Diagnosis and Monitoring from Traditional to Digital Biomarkers. Biosensors, 15(2), 102. https://doi.org/10.3390/bios15020102 DOI
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